CCIT Vacuum Decay Leak Study

In the pharmaceutical industry, products must stay sterile as they are transported. One of the critical steps of
Container Closure Integrity Testing (CCIT) is performing leak testing. A study – by Jayshree Patel et al. – tested
their method to see if it would be faster and more effective. The experiment designed the test as an in-progress package integrity test from manufacturing and tests for stability. This would allow manufactures to
check for any types of defective packaging before mass shipment was approved. The time it takes to test
packages is surprisingly fast at less than one minute per container. The package defects tested can range from
glass vials with testing of the glass walls, to ceiling surface defects. When it came to the hole testing and
drilling of the holes, Lenox Laser was there to help.

When asked by the researchers for the study, Lenox Laser provided hole creation and size certification for the
tests performed. We were able to drill holes the size of or equal to 5 µm in diameter – the precise size needed
for the study. The validation tests used were successfully able to detect the dimensions of the holes in glass
vials. The validation tests were performed at White House Analytical Laboratories in White House, New Jersey.
CCIT is a significant process to what Lenox Laser does, and we take pride in helping any way that we can to
ensure the safety of pharmaceutical packaging.

Lenox Laser can provide many laser drilling needs for different materials, including plastics, nickel, steel, etc.
We can drill any size hole big or small to exact size with precision accuracy if you’d like to learn more about
Lenox Laser services, please visit Lenox Laser Services and our CCIT page. It was a pleasure to assist the
Parental Drug Association in this exciting endeavor of testing. We can’t wait to see the positive effect on the
industry because of this study.

A 2004 Laser Study
Study about Secondary Medical Packaging